| Pair Name | Demethoxycurcumin, AT101 | ||
| Phytochemical Name | Demethoxycurcumin (PubChem CID: 5469424 ) | ||
| Anticancer drug Name | AT101 (PubChem CID: 227456 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Demethoxycurcumin, AT101 | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Gene Regulation | Up-regulation | Phosphorylation | AKT1 | hsa207 |
| In Vitro Model | PC-1 [Human pancreatic carcinoma] | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_S969 |
| PC-2 [Human pancreatic carcinoma Germany] | Pancreatic carcinoma | Homo sapiens (Human) | CVCL_C1YF | |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| Result | Combined treatment with different drugs might be an option to efficiently overcome chemoresistance of GBM cells in a long-term treatment strategy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined treatment of AT101 and demethoxycurcumin yields an enhanced anti-proliferative effect in human primary glioblastoma cells. J Cancer Res Clin Oncol. 2020 Jan;146(1):117-126. doi: 10.1007/s00432-019-03107-7. | Click |
